Nanoparticles Targeting Dendritic Cell Surface Molecules Effectively Block T Cell Conjugation and Shift Response
نویسندگان
چکیده
منابع مشابه
Nanoparticles targeting dendritic cell surface molecules effectively block T cell conjugation and shift response.
Dendritic cells (DCs) are potent professional antigen presenting cells (APC) that activate naïve T cells. Interaction of ICAM-1 and LFA-1 molecules on each cell is required for T cell conjugation to DCs, which leads to naïve CD4+ T cell activation and proliferation. Nanoparticles capable of blocking LFA-1/ICAM-1 interaction were studied as inhibitors of T cell conjugation to DCs. Primary DCs we...
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ژورنال
عنوان ژورنال: ACS Nano
سال: 2011
ISSN: 1936-0851,1936-086X
DOI: 10.1021/nn102159g